Interaction between insulin-like growth factor-1 with other growth factors in serum depleted culture medium for human cartilage engineering.
- Author:
Chua KH
;
Aminuddin BS
;
Fuzina NH
;
Ruszymah BH
- Publication Type:Journal Article
- MeSH:
Cartilage/*transplantation;
Cell Division/physiology;
Chondrocytes/*cytology;
Collagen Type II/genetics;
Culture Media, Serum-Free;
Gene Expression/physiology;
Growth Substances/*physiology;
Insulin-Like Growth Factor I/*physiology;
Tissue Engineering/*methods
- From:
The Medical Journal of Malaysia
2004;59 Suppl B():7-8
- CountryMalaysia
- Language:Malay
-
Abstract:
The regulation roles of insulin-like growth factor-1 (IGF-1) with basic fibroblast growth factor (bFGF) and transforming growth factor beta 2 (TGFbeta2) in human nasal septum chondrocytes monolayer culture and cartilage engineering was investigated in this study. The role of IGF-1 with bFGF and TGFbeta2 was investigated by measuring chondrocyte growth kinetic and collagen genes expression. IGF-1 together with bFGF and TGFbeta2 promote cartilage tissue engineering, increase type II collagen expression and enhance the histological features of engineered cartilage.
