A recombinant 19 kDa Plasmodium berghei merozoite surface protein 1 formulated with alum induces protective immune response in mice.
- Author:
A Wan Omar
;
A M Roslaini
;
Z U Ngah
;
A A Azahari
;
M Zahedi
;
O Baharudin
- Publication Type:Journal Article
- MeSH:
aluminum sulfate;
Laboratory mice;
upper case pea;
Infection as complication of medical care;
protect
- From:Tropical biomedicine
2007;24(1):119-26
- CountryMalaysia
- Language:Malay
-
Abstract:
We investigated the immunogenicity of recombinant rMSP1 (rPbMSP1) that was generated from Plasmodium berghei. The rPbMSP1 formulated in alum was found to be immunogenic which induced high levels of specific anti-rPbMSP1 antibody. The IgG2a response predominated over IgG1 during the challenge infection in the vaccinated mice. Mice vaccinated with rPbMSP1 in alum mounted significant protective immunity against challenge infection (P < 0.01). On day 121 after the booster, three out of ten mice immunized with rPbMSP1 in PBS survived parasite infection (P < 0.05) and eight out of ten mice vaccinated with r MSP1 in alum did (P < 0.01). Hence, immunization with MSP1 in alum obviously has conferred protective effects, which prevented death from P. berghei lethal infection in mice (P < 0.01). These observations provide an excellent model for clinical assessment of this formulation in human subjects.
- Full text:W020150616369531211085.pdf
