The fundamentals of tissue engineering: new scaffolds.
- Author:
L Di Silvio
;
N Gurav
;
R Sambrook
- Publication Type:Journal Article
- MeSH:
Sjogren's syndrome B antibody;
Tritolyl Phosphates;
differentiation;
Tissue Engineering;
Skeletal bone
- From:
The Medical journal of Malaysia
2004;59 Suppl F():89-90
- CountryMalaysia
- Language:Malay
-
Abstract:
The ability to regenerate new bone for skeletal use is a major clinical need. In this study, two novel porous calcium phosphate materials pure HA and biphasic HA/beta-Tricalcium phosphate (HA/beta -TCP) were evaluated as potential scaffolds for cell-seeded bone substitutes using human osteoblast-like cells (HOS) and primary human mesenchymal stem cells (hMSCs). A high rate of proliferation was observed on both scaffolds. A greater increase in alkaline phosphatase (ALP- an indicator of osteoblast differentiation) was observed on HA/beta -TCP compared to HA. This observation indicates that HA/TCP may play a role in inducing osteoblastic differentiation. Although further evaluation is required both materials show potential as innovative synthetic substitutes for tissue engineered scaffolds.
