Heterogeneous t(4;11) fusion transcripts in two infants with acute lymphoblastic leukemia.
- Author:
Harvindar Kaur Gill
;
Sew Keoh Ten
;
Jasbir Singh Dhaliwal
;
Sarah Moore
;
Roshida Hassan
;
Faraiza Abdul Karim
;
Zubaidah Zakaria
;
Shahnaz Murad
;
Mahfuzah Mohamed
;
Hishamshah Mohamad Ibrahim
;
Eni Juraida Abdul Rahman
- Publication Type:Journal Article
- MeSH:
Lower case tea;
Leukemia, Lymphocytic, Acute;
Reverse Transcriptase Polymerase Chain Reaction;
L;
Lower case ecks
- From:The Malaysian journal of pathology
2004;26(2):105-10
- CountryMalaysia
- Language:Malay
-
Abstract:
An RT-PCR assay detected the t(4;11) translocation in two infants with acute lymphoblastic leukemia (ALL). Case P76 was a 10-month-old, female infant, who presented with a WBC of 137.4 x 10(9)/l and a pre-pre-B ALL immunophenotype. Case P120 was a 6-month-old female infant, with a WBC > 615 x 10(9)/l and a pre-pre-B ALL immunophenotype. RT-PCR of cDNA from both these cases generated a 656 bp and a 542 bp respectively, which sequencing confirmed as t(4;11) fusion transcripts. The primers and conditions selected for this assay are compatible with a one-step multiplex PCR for the main translocations in childhood ALL.
