Mantle cell lymphoma--a clinicopathological study of 13 cases.
- Author:
Debdatta Basu
;
Parasappa J Yaranal
;
Koti Kalyan
;
Jayanthi Soundararaghavan
- Publication Type:Journal Article
- MeSH:
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse;
Pattern;
Five;
Lymphoma, Low-Grade;
Lymphoma, Non-Hodgkin's
- From:The Malaysian journal of pathology
2005;27(1):17-22
- CountryMalaysia
- Language:Malay
-
Abstract:
Mantle cell lymphoma is an uncommon non-Hodgkin's lymphoma. In a period of four years, 13 cases of mantle cell lymphoma were diagnosed in our department, comprising 3.1% of all non-Hodgkin's lymphoma diagnosed. The mean age of presentation was 52 years with a slight male preponderance. The disease was nodal in twelve and extra-nodal in tonsil in one. Five patients had bone marrow involvement. Five cases showed a nodular pattern on lymph node biopsy while the remaining eight had a diffuse pattern. Immunophenotyping showed positivity for CD20 and cyclin D1. Despite certain morphological similarity to other low-grade lymphomas, mantle cell lymphoma has a characteristic appearance of its own. It is more aggressive than other low-grade lymphomas and hence needs to be accurately diagnosed.
