Parathyroid Hormone Secreting Metaplastic Breast Carcinoma: A Case Report of Paraneoplastic Syndrome
- Author:
Ahmed MS
;
Nor Faezan AR
;
Rohaizak M
- Publication Type:Case Reports
- Keywords:
Breast carcinoma;
hypercalcaemia;
hyperparathyroidism;
paraneoplastic syndrome
- MeSH:
Breast Neoplasms
- From:Journal of Surgical Academia
2016;6(2):46-49
- CountryMalaysia
- Language:English
-
Abstract:
Paraneoplastic syndrome (PNS) is a distant neurological manifestation of an underlying tumour. Humoral
hypercalcaemia of malignancy is a form of paraneoplastic syndrome where there is an increased in calcium levels. In
this article we report a 48 year old lady, with no known medical illness and presented with symptomatic
hypercalcaemia. She presented to our institution complaining of a fungating and ulcerating mass over the right
breast, measuring 11 X 15 cm and associated with gradual paraxial body weakness. Further investigations revealed
the lesion to be an invasive breast carcinoma with metaplastic features. Computed tomography (CT) scan showed a
locally advanced breast carcinoma with right axillary node metastasis, without evidence of distant metastasis. Serum
calcium, i-PTH together with SPECT has confirmed the patient to have a humoral hypercalcaemia malignancy with
elevated ectopic parathyroid hormone level. Bone scan did not reveal any evidence of metastasis. High volume
intake and loop diuretics were employed in the management of hypercalcaemia, which was eventually resolved
following mastectomy with axillary clearance of the ipsilateral side. Currently she’s she is under oncologist’s follow
up for further management.
- Full text:P020161122403607085884.pdf
