Association between house dust mite (HDM) sensitisation and asthma control using skin prick test and HDM antigen specific IgE levels in saliva of Malaysian children
- Author:
Keat Seong Teo
;
Cheong Wooi Cheah
;
Joon Wah Mak
- Publication Type:Journal Article
- Keywords:
Dermatophagoides pteronyssinus;
Dermatophagoides farina;
childhood asthma;
house dust mite specific-salivary IgE
- MeSH:
Asthma
- From:International e-Journal of Science, Medicine and Education
2015;9(2):3-12
- CountryMalaysia
- Language:English
-
Abstract:
Background: Sensitisation to house dust mite (HDM)
has been regarded as a major risk factor for development
of asthma. This study was carried out to investigate the
profiles of HDM sensitisation among Malaysian children
with asthma.
Material and Methods: The association between HDM
sensitisation and control and severity of asthma was
investigated. The salivary HDM specific IgE levels were
quantified in different grades of control and severity
of asthma in 125 unselected asthmatic children aged
5-12 years old attending the asthma follow-up clinic
in Hospital Tuanku Ja’afar Seremban. An additional
29 non-asthmatic patients were selected as control.
The skin prick test to assess sensitisation
to Dermatophagoides pteronyssinus (DP) and
Dermatophagoides farinae (DF) was performed on all
the participants. A questionnaire regarding the control
and severity of asthmatic symptoms of the subject was
administered. Saliva was collected by voluntary spitting
and ELISA was used to quantify the IgE specific to HDM
antigen.
Results: There was a significant association between
sensitisation to DP and DF and the control of asthma.
The association between DP sensitisation and severity
of asthma just failed to reach a significant level although
there is a clear trend for this. Significant association was
found between DF sensitisation and severity. The HDM
specific IgE in the saliva was significantly higher in
asthmatic patients compared to non-asthmatic patients.
There was no significant difference between the specific
IgE levels in patients with different severity status of
asthma.
Conclusion: Salivary IgE levels may not be an
appropriate indicator of the patients’ asthmatic condition
in this study. However, it can be concluded that there
is significant association between the sensitisation of
HDM and the control and severity of asthma.
- Full text:P020150903522659823117.pdf
