Bioactive molecules: current trends in discovery, synthesis, delivery and testing
- Author:
Yew Beng Kang
;
Pichika R Mallikarjuna
;
Davamani A Fabian
;
Adinarayana Gorajana
;
Chooi Ling Lim
;
Eng Lai Tan
- Publication Type:Review
- Keywords:
Bioactive molecules, compound libraries, surface plasmon resonance, drug delivery, Zebra fish
- From:International e-Journal of Science, Medicine and Education
2013;7(supp1):S32-46
- CountryMalaysia
- Language:English
-
Abstract:
Important bioactive molecules are molecules
that are pharmacologically active derived from natural
sources and through chemical synthesis. Over the years
many of such molecules have been discovered through
bioprospective endeavours. The discovery of taxol from
the pacific yew tree bark that has the ability in stabilising
cellular microtubules represents one of the hallmarks of
success of such endeavours. In recent years, the discovery
process has been aided by the rapid development
of techniques and technologies in chemistry and
biotechnology. The progress in advanced genetics and
computational biology has also transformed the way
hypotheses are formulated as well as the strategies for drug
discovery. Of equal importance is the use of advanced
drug delivery vehicles in enhancing the efficacy and
bioavailability of bioactive molecules. The availability of
suitable animal models for testing and validation is yet
another major determinant in increasing the prospect for
clinical trials of bioactive molecules.
- Full text:W020151005531589950357.pdf
