PET-CT Imaging In Non-Small Cell Lung Carcinoma – A Review of Cases from A Northern Malaysia Referral Centre
- Author:
Joni Bing Fei Teoh
;
Vikneswary Paniandi
;
Fadzilah Hamzah H
;
Mohamed Ali Abdul Khader
;
Li-Cher Loh
- Publication Type:Journal Article
- Keywords:
Carcinoma, Non-Small-Cell Lung;
Positron emission tomography;
Computed tomography;
Malaysia
- From:International e-Journal of Science, Medicine and Education
2008;2(2):23-26
- CountryMalaysia
- Language:English
-
Abstract:
Background: Positron Emission Tomography and
Computed Tomography (PET-CT) imaging is shown to
influence a decision change in managing non-small cell
lung carcinoma (NSCLC). The introduction of such a
facility in Malaysia is relatively recent, and its impact
from its utility is currently being assessed.
Aim: In a tertiary referral centre possessing the only
PET-CT facility in northern Peninsular Malaysia,
we evaluated the potential roles of PET-CT in referred
patients with non-small cell lung carcinoma.
Methodology: Sixty eligible adult cases with NSCLC,
between September 2005 and December 2007,
were retrospectively reviewed. Relevant data was
collected using standard questionnaire for indications,
staging of disease, and outcomes in terms of recurrence
and response to prescribed cancer-specific therapy.
Results: The indications for PET-CT were: staging of a
newly diagnosed non-small cell lung carcinoma
(25.0%); post-operative restaging (21.7%); exclusion of
recurrence or metastasis (18.3%); establishing diagnosis
of carcinoma (13.3%); assessment of response to
treatment (11.7%), and for surveillance (10.0%). The
use of PET-CT was shown to induce a change in the
staging, compared with non-PET conventional means
in 69.2% of patients with newly diagnosed lung
carcinoma (upstaged in 55.5%; downstaged in 44.5%)
and in 65.0% of patients who underwent cancer-specific
treatments (upstaged in 38.5%; downstaged in 61.5%).
PET-CT detected recurrence in 62.5% who underwent
the imaging to exclude a recurrence or metastasis.
Conclusion: PET-CT has affected the staging of
a large proportion of our local Malaysian patients.
Like elsewhere, the availability of such a facility is likely to have important influence in overall management of
NSCLC in Malaysia.
- Full text:W020150928409889353321.pdf
