Survey of perinatal hepatitis B virus transmission after Korean National Prevention Program in a tertiary hospital.
10.3904/kjim.2014.29.3.307
- Author:
Jae Hoon KIM
1
;
Ju Seung KIM
;
Jong Joon LEE
;
Jung Ho KIM
;
Suk Young KIM
;
Young Kul JUNG
;
Oh Sang KWON
;
Yun Soo KIM
;
Duck Joo CHOI
;
Ju Hyun KIM
Author Information
1. Gachon University School of Medicine, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
Hepatitis B;
Vaccination;
Vertical infection transmission;
Korea
- MeSH:
Adult;
Biological Markers/blood;
DNA, Viral/blood;
Female;
Health Surveys;
Hepatitis B/blood/diagnosis/epidemiology/prevention & control/*transmission/virology;
Hepatitis B Surface Antigens/blood;
Hepatitis B e Antigens/blood;
Hepatitis B virus/genetics/immunology;
Humans;
Infant, Newborn;
*Infectious Disease Transmission, Vertical/prevention & control;
*National Health Programs;
Pregnancy;
Prevalence;
Republic of Korea/epidemiology;
Retrospective Studies;
*Tertiary Care Centers;
Viral Load
- From:The Korean Journal of Internal Medicine
2014;29(3):307-314
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The Ministry of Health and Welfare and the Korea Centers for Disease Control and Prevention in South Korea have been organizing hepatitis B virus (HBV) vertical infection prevention projects since July 2002. In this single-institute study, the results of surveys conducted in target mothers who delivered babies in a tertiary hospital were investigated and analyzed. METHODS: Of the 9,281 mothers and their 9,824 neonates born between July 2002 and December 2012, 308 hepatitis B surface antigen (HBsAg)-positive mothers and their 319 neonates were selected for this study, and their records were analyzed retrospectively. RESULTS: A total of 308 mothers were HBsAg-positive, with an HBV prevalence of 3.32% (308/9,281). There were 319 neonates born to these HBsAg-positive mothers, and 252 were confirmed to as either HBsAg-positive or -negative. Four were confirmed as HBsAg-positive, with a 1.59% (4/252) HBV vertical infection rate. All the mothers of neonates who had an HBV vertical infection were hepatitis B e antigen (HBeAg)-positive. Among the HBsAg-positive neonates, three were HBeAg-positive and had an HBV DNA titer of 1.0 x 10(8) copies/mL. CONCLUSIONS: The HBV prevalence of mothers was 3.32% (308/9,281), and their vertical infection rate was 1.59% (4/252). Thus, the South Korean HBV vertical infection prevention projects are effective, and, accordingly, HBV prevalence in South Korea is expected to decrease continuously.
