Urinary excretion of beta2-microglobulin as a prognostic marker in immunoglobulin A nephropathy.
10.3904/kjim.2014.29.3.334
- Author:
Jae Ryung SHIN
1
;
Seung Min KIM
;
Jung Sun YOO
;
Ji Yoon PARK
;
Seul Ki KIM
;
Joo Hee CHO
;
Kyung Hwan JEONG
;
Tae Won LEE
;
Chun Gyoo IHM
Author Information
1. Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea. cgihm@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Urinary beta2-microglobulin;
Glomerulonephritis, IGA;
Prognostic factor
- MeSH:
Adult;
Biological Markers/blood/urine;
Biopsy;
Creatinine/blood/urine;
Disease Progression;
Female;
Glomerular Filtration Rate;
Glomerulonephritis, IGA/blood/diagnosis/physiopathology/*urine;
Humans;
Inpatients;
Linear Models;
Male;
Middle Aged;
Multivariate Analysis;
Predictive Value of Tests;
Prognosis;
Proportional Hazards Models;
Proteinuria/blood/diagnosis/physiopathology/*urine;
Risk Factors;
Young Adult;
beta 2-Microglobulin/*urine
- From:The Korean Journal of Internal Medicine
2014;29(3):334-340
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: beta2-microglobulin (beta2-MG) is freely filtered at the glomerulus and subsequently reabsorbed and catabolized by proximal renal tubular cells. Urinary beta2-MG is an early and sensitive biomarker of acute kidney injury; however, its utility as a biomarker of immunoglobulin A nephropathy (IgAN) is unclear. METHODS: We included urinary beta2-MG levels in the routine laboratory examination of all inpatients with biopsy-proven IgAN at our hospital from 2006 to 2010. We retrospectively analyzed the correlation between beta2-MG levels and clinical parameters as a prognostic biomarker of IgAN. RESULTS: A total of 51 patients (30 males, 21 females; mean age, 33.01 +/- 12.73 years) with IgAN were included in this study. Initial demographic, clinical, and laboratory data for all patients are listed. The mean initial estimated glomerular filtration rate and 24-hour urine protein levels were 94.69 +/- 34.78 mL/min/1.73 m2 and 1.28 +/- 1.75 g/day, respectively. The mean level of urinary beta2-MG was 1.92 +/- 7.38 microg/mg creatinine. There was a significant correlation between initial serum creatinine (iSCr), urine protein creatinine ratio (UPCR), and the level of beta2-MG (r = 0.744, r = 0.667, p < 0.01). There was also a significant correlation between renal function tests and the level of urinary beta2-MG (p < 0.01). Cox regression analysis showed that albumin, beta2-MG, iSCr, and UPCR were significant predictors of disease progression in IgAN. CONCLUSIONS: Urinary beta2-MG levels showed a significant correlation with renal function and proteinuria in IgAN. Thus, we propose that urinary beta2-MG may be an additional prognostic factor in patients with IgAN.
