A Comparison of Ultrasonography, Computerised Tomography, and Conventional MRI Findings for Splenic Nodules Associated with Type 1 Gaucher s Disease with Diffusion-Weighted MRI Findings
- Author:
Eda Albayrak
;
Fitnet Sonmezgoz
;
Zafer Ozmen
;
Fatma Aktas
;
Aysegul Altunkas
- Publication Type:Case Report
- Keywords:
diffusion magnetic resonance imaging;
lysosomal storage diseases;
multidetector computed tomography
- From:Malaysian Journal of Medical Sciences
2017;24(5):112-118
- CountryMalaysia
- Language:English
-
Abstract:
A 26-year-old female patient with Type 1 Gaucher’s disease (GD) was admitted to
our clinic with complaints of stomachache and signs of anemia. The patient underwent
ultrasonography (US), computerised tomography (CT), and magnetic resonance imaging (MRI)
scan. Imaging studies revealed massive hepatosplenomegaly, choledocolithiasis, and six nodules
in the spleen with a mean size of 14 mm. The nodules appeared hyperechoic, hypoechoic, and
of mixed echogenicity on the US and hypodense on the CT. While the nodules were observed to
be iso-hypointense in T1-weighted (T1WI) images, they appeared to be hyperintense in the T2-
weighted (T2WI) images. There were no diffusion restrictions in these nodules that appeared on
the diffusion-weighted magnetic resonance imaging (DWI). A nodule located at the lower pole
was observed to be hypointense in the T2WI images. The nodule located at the lower pole, which
appeared hypointense in T2WI series, had restricted diffusion upon DWI.
In this study, we aimed to present the properties of splenic GD nodules using US,
CT, and conventional MRI, together with DWI. This case report is the first to apply US, CT, and
conventional MRI, together with DWI, to the splenic nodules associated with Gaucher’s disease.
