Sample Size Calculation in Animal Studies Using Resource Equation Approach
- Author:
Wan Nor Arifin
;
Wan Mohd Zahiruddin
- Publication Type:Journal Article
- Keywords:
animal research;
research design;
sample size
- From:Malaysian Journal of Medical Sciences
2017;24(5):101-105
- CountryMalaysia
- Language:English
-
Abstract:
Animal research plays an important role in the pre-clinical phase of clinical trials.
In animal studies, the power analysis approach to sample size calculation is recommended.
Whenever it is not possible to assume the standard deviation and the effect size, an alternative to
the power analysis approach is the ‘resource equation’ approach, which sets the acceptable range
of the error degrees of freedom (DF) in an analysis of variance (ANOVA). The aim of this article is
to guide researchers in calculating the minimum and maximum numbers of animals required in
animal research by reformulating the error DF formulas.
