Response to intradermal autologous platelet rich plasma injection in refractory dermal melasma: report of two cases
- Author:
Yew CH
;
Ramasamy TS
;
Amini F
- Publication Type:Case Reports
- Keywords:
Alpha arbutin;
Melasma;
Platelet rich plasma;
PRP;
Q-switched Nd Yag laser
- MeSH:
Melasma
- From:Journal of University of Malaya Medical Centre
2015;18(2):1-6
- CountryMalaysia
- Language:English
-
Abstract:
Refractory dermal melasma is resistant to conventional treatment. Platelet rich plasma (PRP) may help to reduce
the pigmentation of melasma. We present a case report on the clinical outcome of 2 patients with melasma,
given PRP, as an adjunct therapy. PRP was administered at a monthly interval for 2 sessions in combination
with a monthly Q-switched Nd Yag laser treatment and topical alpha arbutin application. A modified melasma
area and severity index (MASI) was evaluated by two dermatologists who were blinded. At the follow up on
the 3rd months, the MASI score was reduced by mean 33.5% for case 1 and 20% for case 2. There were no
clinical complications for case 1. However recurrence of melasma was noted in case 2 by a worsening of the
MASI score mean to 53% at the sixth months follow up. In conclusion, intradermal PRP injection as an adjunct
to the conventional treatment of melasma presented with differing results in two cases.
- Full text:P020151007562520422074.pdf
