Posterior reversible encephalopathy syndrome: Malaysian haemato-oncological paediatric case series
- Author:
Choong Yi Fong
;
Chaw Su Hlaing
;
Aye Mya Min Aye
;
Chee Geap Tay
;
Hany Ariffin
;
Lai Choo Ong
- Publication Type:Journal Article
- MeSH:
Posterior Leukoencephalopathy Syndrome;
Brain Diseases
- From:Neurology Asia
2015;20(3):275-281
- CountryMalaysia
- Language:English
-
Abstract:
Background & Objective: Posterior reversible encephalopathy syndrome (PRES) is associated with
immunosuppressive agents used in children with haemato-oncological diseases. There are no reports
to date from the South Asia and South East Asia region. We report a Malaysian tertiary centre case
series of children with haemato-oncological disease who developed PRES. Methods: Retrospective
study of children seen with haemato-oncology diseases seen at the University Malaya Medical Centre
Kuala Lumpur who developed PRES from 2011 – 2013. Clinical details were obtained from medical
records and brain neuroimaging was reviewed. Results: Five patients met the inclusion criteria. All
5 patients had significant hypertension acutely or subacutely prior to neurology presentation. Four
presented with acute seizures and the remainder 1 presented with encephalopathy.Three patients
were on chemotherapy, 1 had renal impairment and 1 had prior immunosupression for bone marrow
transplantation. A full recovery was seen in 4 patients and 1 patient had mild residual quadriplegia.
Conclusion: Our case series expands the clinico-radiological spectrum of PRES in children with
underlying haemato-oncological disorders. It is the first to show that prior cyclosporin intake as long
as 2 months is a potential risk factor for PRES. Clinicians need to be vigilant for development of
PRES and closely monitor the blood pressure in these children who are receiving or recently had
immunosuppressive drugs and present with acute neurological symptoms.
- Full text:P020151007462659801413.pdf
