Lack of association between ABCC2 polymorphisms and plasma carbamazepine concentrations or pharmacoresistance in Chinese patients with epilepsy
- Author:
Zhuo Wan
;
Hongmei Meng
;
Yan Bai
;
Yi Bai
;
Yang Dong
;
Min Liang
;
Yingjie Guo
- Publication Type:Journal Article
- MeSH:
Epilepsy
- From:Neurology Asia
2015;20(3):221-227
- CountryMalaysia
- Language:English
-
Abstract:
Multidrug resistance proteins (MRP2, ABCC2) may play a role in drug resistance in epilepsy by
limiting gastrointestinal absorption and brain access of antiepileptic drugs (AEDs). We sought to
investigate the effects of ABCC2 polymorphisms on plasma carbamazepine (CBZ) concentrations
and pharmacoresistance in Chinese patients with epilepsy. ABCC2 rs717620, rs2273697, rs3740066
polymorphisms were genotyped by polymerase chain reaction amplification followed by restriction
fragment length polymorphism analysis or direct automated DNA sequencing in 80 patients treated
with CBZ monotherapy. There were no differences in CBZ maintenance doses or adjusted plasma
CBZ concentrations among the ABCC2 rs717620, rs2273697 and rs3740066 genotypic groups.
No associations between all the studied genotypes and haplotypes involving the three SNPs of
ABCC2 and CBZ resistance were observed in this patient cohort. These results suggest that ABCC2
polymorphisms may not contribute to interindividual variabilities in CBZ daily maintenance doses,
plasma concentrations, and treatment efficacy.
- Full text:P020151007425632145753.pdf
