Daily dose of dopaminergic medications in Parkinson disease: Clinical correlates and a posteriori equation
- Author:
Jee-Young Lee
;
Jae Woo Kim
;
Won Yong Lee
;
Jong-Min Kim
;
Tae-Beom Ahn
;
Han-Joon Kim
;
Jinwhan Cho
;
Beom S Jeon
- Publication Type:Journal Article
- From:Neurology Asia
2010;15(2):137-143
- CountryMalaysia
- Language:English
-
Abstract:
Objectives: To survey daily doses of dopaminergic medications and to draw a posteriori equation of the
dose in relation to the various clinical variables in Korean patients with Parkinson disease. Methods:
A multi-center cross-sectional survey was conducted over a defi ned period. Information on patient
demographics and clinical features including age at Parkinson disease onset, disease duration, treatment
duration and Hoehn and Yahr stage, and daily doses of anti-parkinsonian drugs was obtained from
the patients’ medical records. Results: A total of 1,762 patients with Parkinson disease were recruited
from 6 referral centers. The mean L-dopa equivalent daily dose (LEDD) in the whole population was
608.9 mg/day, which tended to increase linearly depending on the duration of disease and Hoehn and
Yahr stage. LEDD was also signifi cantly affected by age and gender. We performed multiple linear
regression analyses and devised a posteriori equation of LEDD with clinical variables.
Conclusions: This survey provides systematic data for mean LEDD in Korean Parkinson disease
patients. In spite of profound individual variations in LEDD, our linear regression model provides an
insight about the relationship between daily doses of dopaminergic medications and various clinical
features of Parkinson disease.
- Full text:P020150902391155821970.pdf
