Genes associated with Alzheimer Disease
- Author:
Anjana Munshi
;
YR Ahuja
- Publication Type:Review
- From:Neurology Asia
2010;15(2):109-118
- CountryMalaysia
- Language:English
-
Abstract:
Alzheimer’s disease (AD) is one of the neurodegenerative disorders, characterized by gradual loss of
memory, decline in other cognitive functions and decrease in functional capacity. Increasing age and
a positive family history of dementia are the defi nite risk factors of the disease. Molecular analysis of
families with early onset of AD (EOAD) has made it possible to identify dominantly acting mutations
in genes such as amyloid precursor protein precursor protein and presenilin 1 and 2 (PSEN 1 & PSEN
2). However, the etiology of the late onset of AD (LOAD) is less straightforward than EOAD. The
availability of novel genetic tools such as high throughput methods for single nucleotide polymorphism
(SNP) genotyping, which simultaneously genotype hundreds of thousands of SNPs using a single SNP
array, may facilitate the discovery of genetic infl uences in the disease. These genome-wide association
studies have great potential to revolutionize our ability to identify additional genes that contribute to
the risk of sporadic AD. It is hoped that the identifi cation of individuals with a high genetic risk of
AD will help to develop more rational, cost effective and novel prevention strategies and therapeutic
approaches.
- Full text:P020150902380360513164.pdf
