Alfa-Synuclein polymorphism and Parkinson’s disease in a tau homogeneous population
- Author:
Hee Jin Kim
;
Jong-Min Kim
;
Jee-Young Lee
;
Sung Sup Park
;
Beom S Jeon
- Publication Type:Journal Article
- From:Neurology Asia
2010;15(1):61-63
- CountryMalaysia
- Language:English
-
Abstract:
Background & Objective: The MAPT H1 haplotype and SNCA single nucleotide polymorphism (SNP)
rs356219 have been reported to have a synergistic effect on the risk of Parkinson’s disease (PD).
Because the H1/H1 genotype has been reported to predominate in Korean population, we investigated
the polymorphism of rs356219 in 878 PD patients and 559 controls. Methods: The SNCA SNP rs356219
was analyzed in 878 PD patients and in 559 healthy Korean subjects. Results: The G allele of SNCA
SNP rs356219 was found to contribute to PD susceptibility with odds ratios (ORs) similar to those
reported previously. However, the ORs were not as large as that of the SNCA rs356219 plus MAPT
H1/H1 combination reported in the literature, which cast doubt on the existence of a synergistic effect
between the two genotypes in our population.
Conclusions: This study supports that the G allele of the SNCA SNP rs356219 contributes to PD
susceptibility as reported previously, but it does not support the presence of a synergistic interaction
between SNCA and MAPT.
- Full text:P020150902366805518433.pdf
