Plasma level of nitrates in patients with Parkinson’s disease in West Bengal
- Author:
Jaya Sanyal
;
BN Sarkar
;
Tapas Kumar Banerjee
;
Subhash Chandra Mukherjee
;
Bidhan Chandra Ray
;
VR Rao
- Publication Type:Journal Article
- From:Neurology Asia
2010;15(1):55-59
- CountryMalaysia
- Language:English
-
Abstract:
Background: Oxidative stress is implicated as a major factor for nigral neuronal cell death. It has been
suggested that nitric oxide (NO) might be responsible in the neuronal degeneration of substantia nigra
compacta in patients with Parkinson’s disease (PD). Methods: To elucidate the possible role of NO
as a risk factor for PD, we determined the plasma levels of nitrate in 80 PD patients and 80 age and
sex-matched controls. Results: There was a signifi cant difference between the mean plasma nitrate
level of PD patients (34.5 ± 4.2 μmol/l) vs. controls (31.8 ± 3.15 μmol/l) (P<0.001). Moreover, there
was a positive correlation in PD patients between plasma nitrate level and age, age at disease onset,
duration of disease, Hoehn and Yahr stage, and Unifi ed Parkinson’s Disease Rating Scale (UPDRS)
score. However, PD patients with short disease duration did not have elevated plasma nitrate levels
compared to control subjects.
Conclusion: Our results argue against the hypothesis that NO is important in the development of PD
in West Bengal.
- Full text:P020150902361249267073.pdf
