Imaging small animal models of epileptogenesis
- Author:
Bianca Jupp
;
John Williams
;
David Binns
;
Rodney Hicks
;
Terence O’Brien
- Publication Type:Journal Article
- From:Neurology Asia
2007;12(Supplement 1):51-54
- CountryMalaysia
- Language:English
-
Abstract:
In-vivo neuroimaging of small animal models of epilepsy offers the ability to serially examine the
progressive structural and functional changes that occur during the development of chronic epilepsy
(i.e. epileptogenesis). Such approaches allow the correlation of imaging findings to the etiology,
development, progression, treatment and prognosis of epilepsy in animal models, associations that are
poorly understood clinically. MRI and PET imaging of the kindling and kainic acid models of TLE
have begun to piece together the relationship of structural and functional changes in the brain during
epileptogenesis and their relationship to seizure and histological outcomes.
- Full text:P020150828597700049483.pdf
