Diagnosis of Cerebrovascular Disease Using 99mTc-HMPAO SPECT.
- Author:
Do Heum YOON
1
;
Seung Kon HUH
;
Kyu Chang LEE
;
Do Yun LEE
;
Tae Sub CHUNG
Author Information
1. Department of Neurosurgery, Yonsei University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
99mTc-HMPAO;
SPECT;
rCBF;
Cerebrovascular disease
- MeSH:
Brain;
Diagnosis*;
Humans;
Perfusion;
Regional Blood Flow;
Technetium Tc 99m Exametazime*;
Tomography, Emission-Computed, Single-Photon*
- From:Journal of Korean Neurosurgical Society
1988;17(5):1029-1034
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A new radiopharmaceutical, technetium-99m hexamethylpropyleneamine oxime(99mTc-HMPAO), has been reported to cross the blood-brain-barrier and to distribute in brain in proportion to regional blood flow. Measurement of cerebral blood flow with single photon emixxion computed tomography(SPECT) was performed using 99mTc-HMPO in 46 patients and clinical analysis was done. Decreased regional cerebral perfusion was observed in 41 cases. Moreover eight cases of them who had normal X-ray C-T scan revealed positive finding on SPECT. We porpose that 99mTc-HMPAO SPECT seems to be a useful diagnostic method for evaluation of ischemic cerebral lesions.
