Neurobiological links between epilepsy and mood disorders
- Author:
Michael Salzberg
- Publication Type:Journal Article
- From:Neurology Asia
2011;16(Supplement 1):37-40
- CountryMalaysia
- Language:English
-
Abstract:
With increasing realization of the extent and consequences of depressive comorbidity in epilepsy,
much human and animal research has focussed on its explanation. Recent studies tackle all three
explanatory possibilities: that epilepsy leads to depression; that depression contributes to causation
of epilepsy; or that shared causal factors or processes lead to both epilepsy and depression. These are
not mutually exclusive; all three probably contribute. Animal models have provided many insights
into the interplay between epilepsy and depressive-like behaviours, both associations and mechanisms.
Notably, experimental stress potently affects epilepsy endpoints, as well as depressive-like behaviour,
having actions at multiple relevant biological levels. Current general (nonepilepsy) depression
modelling is biopsychosocial in nature, integrating insights from genetics, epidemiology, psychology
and neurobiology; and takes a lifespan developmental perspective, as the causation of depression is
a multistage process with origins in early life - as is the case for many epilepsies. These perspectives
need to be more fully adopted in the epilepsy/depression fi eld.
- Full text:P020150824385683329793.pdf
