Genetics of large populations in epilepsy: Association studies – Trials and tribulations
- Author:
Nigel CK Tan
- Publication Type:Journal Article
- From:Neurology Asia
2011;16(Supplement 1):9-10
- CountryMalaysia
- Language:English
-
Abstract:
Unlike Mendelian epilepsies, complex epilepsies may be due to the effect of several or multiple
susceptibility genes. Association studies have been used in the past decade to help identify common
genetic variants underpinning complex epilepsies. However, as the data in the Epilepsy Genetic
Association Database (epiGAD) show, many of these studies have been negative, or have shown
confl icting results. Overall, most putative gene-disease associations are weak. Inadequate sample size
is the most likely cause. Multicentre collaborations are vital.
- Full text:P020150821579744418794.pdf
