Age-related white matter changes in Asia
- Author:
Yun Yun Xiong
;
Vincent Mok
- Publication Type:Review
- From:Neurology Asia
2011;16(3):179-186
- CountryMalaysia
- Language:English
-
Abstract:
Age-related white matter changes are common in the elderly and are considered as manifestation of
arteriolosclerotic small vessel disease. Most recent studies have shown that the white matter changes are
associated with cognitive impairment and dementia, urinary incontinence, gait disturbances, depression
and increased risk of stroke and death. Although the clinical phenotypes of the white matter changes
have been extensively studied, to date, only few clinical trials have been conducted in this area. In this
review, we discussed the current understanding in the epidemiology, pathogenesis, imaging features,
chemical biomarkers, clinical importance, and management of age-related white matter changes, with
special emphasis in studies that were conducted among Asians.
- Full text:P020150805575923818862.pdf
