Pathology of Henipavirus infection in humans and hamster model
- Author:
KT Wong
- Publication Type:Journal Article
- From:Neurology Asia
2009;14(1):59-61
- CountryMalaysia
- Language:English
-
Abstract:
Hendra and Nipah viruses (genus: Henipavirus) are novel paramyxoviruses that emerged to cause
severe human and animal disease. Studies in both humans and animals suggest that both viral infections
are associated with similar pathologies. This is probably related to the common viral receptors
that henipaviruses employ to infect the cell. The blood vessels and central nervous system tissues
were particularly susceptible. A dual pathogenetic mechanism of vasculitis-associated thrombosis/
microinfarction and direct parenchymal cell infection contributed to acute tissue injury. A unique
relapsing encephalitis may also complicate henipavirus infection.
- Full text:P020150901604655981138.pdf
