Analysis of cerebrospinal fl uid cytokines and growth factors in multiple sclerosis patients with and without chronic headaches
- Author:
Hikaru Doi
;
Takuya Matsushita
;
Noriko Isobe
;
Takahisa Tateishi
;
Jun-ichi Kira
- Publication Type:Journal Article
- From:Neurology Asia
2011;16(1):65-70
- CountryMalaysia
- Language:English
-
Abstract:
Background: We previously reported that, in Japanese patients with multiple sclerosis (MS), the
frequency of chronic headaches was signifi cantly higher after administration of interferon beta (IFNβ).
However, the mechanisms underlying IFNβ-related chronic headaches were unknown. Objective: To
clarify the mechanisms underlying IFNβ-induced chronic headaches in MS patients by analyzing
cytokine levels in cerebrospinal fl uid (CSF). Methods: We measured the levels of 27 CSF cytokines
and growth factors using a fl uorescent bead-based immunoassay, during a headache-free period, in 34
MS patients enrolled in our previous survey on chronic headaches. Results: There were no signifi cant
differences in CSF cytokine levels between the 21 MS patients with chronic headaches and the 13
without chronic headaches. Among the 14 patients receiving IFNβ therapy, the 5 patients with chronic
headaches showed signifi cantly lower levels of interleukin (IL) 15, IL17 and chemokine (C-C motif)
ligand 2 (CCL2) (also known as monocyte chemoattractant protein 1; MCP1) compared with the 9
patients without chronic headaches (P < 0.05).
Conclusions: The present survey revealed that in MS, chronic headache sufferers on IFNβ therapy
had decreased levels of IL15, IL17 and CCL2 in CSF. This suggests that chronic headaches may tend
to develop in good responders to IFNβ.
- Full text:P020150731426322726887.pdf
