Enterovirus 71 in Malaysia: A decade later
- Author:
Yoke-Fun Chan
;
I-Ching Sam
;
Kai-Li Wee
;
Sazaly Abubakar
- Publication Type:Review
- From:Neurology Asia
2011;16(1):1-15
- CountryMalaysia
- Language:English
-
Abstract:
In the last decade, Malaysia has experienced several hand, foot and mouth disease (HFMD) epidemics,
complicated by fatalities due to severe neurological involvement. Enterovirus 71 (EV-71) has been
implicated as the major causative agent for these epidemics. EV-71 infection is a global public health
problem with pandemic potential. In many parts of Asia-Pacifi c, the virus has emerged as one of the
most deadly virus infections amongst young children. The virus is highly transmissible through faecaloral
route and respiratory droplets. A recent rise in neurological complications and deaths suggests
that the viruses currently circulating may be more virulent. The major risk factor associated with
more severe EV-71 infection is young age and poor cellular immunity. Rapid laboratory diagnosis and
molecular surveillance is important to closely monitor the emergence of new EV-71 subgenotypes.
Since vaccine and anti-virals for EV-71 are not available, control and prevention strategies remain
the only ways to combat the infection.
- Full text:P020150731370215066937.pdf
