The differences in brain damage between asphyxial nd ventricular fibrillation cardiac arrests
- Author:
Qingming Lin
;
Shen Zhao
;
Heng Li
;
Xiangshao Fang
;
Yue Fu
;
Lili Zhou
;
Zitong Huang
- Publication Type:Journal Article
- From:Neurology Asia
2013;18(3):303-309
- CountryMalaysia
- Language:English
-
Abstract:
Objective: Asphyxia and ventricular fibrillation are the two most prevalent causes of cardiac arrest. The
study investigated the differences in brain damage after cardiac arrest between asphyxial and ventricular
fibrillation cardiac arrests in rats. Methods: Male healthy Sprague-Dawley rats were randomly assigned
to the asphyxial group (cardiac arrest of 6 min, n=15), ventricular fibrillation group (cardiac arrest of
6 min, n=15) and sham group (n=5). Neurologic deficit scores and tape removal test were evaluated
at 1, 3 and 7 days after cardiopulmonary resuscitation from three groups. Serum S-100B and brain
histopathologic damage scores were also examined. Results: There were no differences in neurologic
performance at 1, 3 and 7 days after cardiopulmonary resuscitation between the asphyxial group and
ventricular fibrillation group (P>0.05, respectively). Serum S-100B level was higher in the asphyxial
group at 1, 3 and 7 days, compared with the ventricular fibrillation group (P<0.05, respectively). There
were significantly higher histopathologic damage scores at 1, 3 and 7 days in the asphyxial group
compared with the ventricular fibrillation group (P<0.05, respectively).
Conclusion: Asphyxial cardiac arrest has worse morphologic brain damage compared with ventricular
fibrillation cardiac arrest, but the functional brain damage caused by asphyxial cardiac arrest is similar
to that caused by ventricular fibrillation cardiac arrest.
- Full text:P020150706563421106131.pdf
