Post-weaning social isolation regulates social exposure-induced vasopressin release in the paraventricular nucleus
- Author:
Yu Wang
;
Shu-min Deng
;
Qun-ying Fu
;
Xu Liu
- Publication Type:Journal Article
- From:Neurology Asia
2013;18(3):293-301
- CountryMalaysia
- Language:English
-
Abstract:
Background & Objective: Early life stresses, such as social isolation, have lasting effects on the
development of emotion and behavior, in which vasopressin plays important roles. This study aimed
to assess the possible association of central release of vasopressin with social isolation. Methods:
The social isolation model was performed in male mice who endured 6-week social isolation after
weaning. Vasopressin expression in the paraventricular nucleus of hypothalamus (PVN) was measured
with immunohistochemistry. Released vasopressin from PVN was measured with radioimmunoassay.
Results: Vasopressin immunoreactive cells number decreased in the PVN, medial parvocellular division
in social isolation-reared mice, compared to the group-reared counterparts. Social isolation decreased
short social exposure-induced vasopressin release from PVN. Isolation-reared mice exhibited anxiogenic
profile and difficulty in social recognition.
Conclusions: This study provides new evidence for the important role of vasopressin in the development
of emotional and social behaviors.
- Full text:P020150706560279709535.pdf
