An association study between genetic variants at mu-opioid receptor, dopamine transporter, catechol-O-methyltransferase, and dopamine genes and risk of Parkinson’s disease
- Author:
Pang-Ying Shih
;
Tze-Kiong Er
;
Jan-Gowth Chang
- Publication Type:Journal Article
- From:Neurology Asia
2013;18(3):279-287
- CountryMalaysia
- Language:English
-
Abstract:
Background: Parkinson’s disease (PD) is a complex disorder that involves multiple genetic and
environmental factors. Several candidate genes have been speculated to be involved in the development
of PD. We conducted a case-control study to investigate the association between PD and single
nucleotide polymorphisms (SNP) at the OPRM1, DAT, COMT and DRD2 genes in a Taiwanese
population. Methods: The study included 260 PD cases and 100 healthy controls. SNPs at OPRM1
(rs1799971), DAT (rs2652510 and rs2550956), COMT (rs4680) and DRD2 (rs1800497) were determined
by high-resolution melting (HRM) analysis using a LightCycler®480 instrument. Each genotype was
confirmed by direct sequencing. The genotype was checked for Hardy-Weinberg equilibrium. Results:
The chi-square test (χ2
) was used to examine the association between SNP genotypes and PD. The
OPRM1 (rs1799971), DAT (rs2652510 and rs2550956), COMT (rs4680) and DRD2 (rs1800497)
polymorphisms showed no association with PD. Notably, an additional meta-analysis indicated that
DAT rs2652510 was significantly associated with PD risk.
Conclusions: In the Taiwanese population the frequency of the OPRM1, DAT, COMT, and DRD2
genotypes exhibits no difference between the PD patients and normal controls. The meta-analysis of
the original and available data from published studies resulted in significant p values <0.01 for DAT
rs2652510.
- Full text:P020150706556656733899.pdf
