Moyamoya syndrome associated with vitamin B12 defi ciency and hyperhomocysteinemia in a child
- Author:
Rajesh Verma
;
Prakash Kori
;
HN Praharaj
;
Mani Gupta
- Publication Type:Journal Article
- From:Neurology Asia
2012;17(4):361-364
- CountryMalaysia
- Language:English
-
Abstract:
Moyamoya disease is a rare clinical disorder, characterized by chronic, progressive occlusion of
supraclinoid internal carotid artery and proximal portions of the anterior and middle cerebral arteries, and
consequent development of collateral vessels seen on imaging as puff of smoke appearance. Although
the pathophysiology is unclear, various hematologic disorders have been associated with development
of the moyamoya syndrome. We report a case of moyamoya syndrome in a 3 yr old girl who presented
with recurrent ischemic strokes. The angiography was suggestive of moyamoya syndrome. The serum
vitamin B12 level was remarkably low with bone marrow picture of megaloblastic anemia. There was
also hyperhomocysteinemia. Moyamoya syndrome has not been previously reported to be associated
with vitamin B12 defi ciency. We propose that vitamin B12 defi ciency with hyperhomocysteinemia
could result in greater risk for arterial thrombosis and thus caused the moyamoya syndrome in our patient
- Full text:P020150710542109556791.pdf
