No apparent association between beta-amyloid deposition and apolipoprotein E genotype in the non-demented aging brain in a Malaysian population
- Author:
Koon Chu Yaiw
;
Lin Chuan Eu
;
Chee Mun Fang
;
Beng Beng Ong
;
Rajes Qvist
;
Kum Thong Wong
- Publication Type:Journal Article
- From:Neurology Asia
2012;17(4):325-330
- CountryMalaysia
- Language:English
-
Abstract:
Little is known about the relationship between cerebral beta amyloid (Aβ) deposition and apolipoprotein
E (ApoE) genotype in either Alzheimer disease or the aging brain in multi-ethnic Southeast Asia. We
prospectively examined Aβ deposition in relation to ApoE genotype in 50 normal, non-demented,
aging brains drawn from a Malaysian population, aged 52-92 years, using immunohistochemistry
to detect Aβ and direct PCR sequencing for genotyping. The prevalence of Aβ deposition was 8%.
There was no apparent association between Aβ deposition and possession of the ApoE ε4 allele in
our cohort. Out of 4 cases with Aβ deposition, only one case was heterozygous for the ε4 allele; 3
cases did not have the ε4 allele. The Aβ deposition appears to increase with age and is more likely
to be vascular-type deposition (cerebral amyloid angiopathy) rather than parenchymal deposition in
the form of diffuse and neuritic plaques. A larger sample size with more cases of ApoE ε4 and Aβ
deposition is needed to provide conclusive evidence for the apparent non-association between ApoE
ε4 and Aβ deposition in the aging brain in our multi-ethnic local population.
- Full text:P020150710519546436098.pdf
