Protective effect of dorsal longitudinal myelotomy at 72 Hours after spinal cord injury in rat model
- Author:
Rui Gu
;
Xin Zhang
;
Degang Yang
;
Wei Sun
;
Mingliang Yang
;
Liangjie Du
;
Feng Gao
;
Jianjun Li
- Publication Type:Journal Article
- From:Neurology Asia
2012;17(2):141-146
- CountryMalaysia
- Language:English
-
Abstract:
Incision of the spinal cord (myelotomy) after spinal cord injury (SCI) is a surgical treatment which
is mainly performed within 24 hours after SCI. However, many patients are fi rst seen outside the
established time window of 24 hours. Furthermore, little attention has been given to its effi cacy and
mechanism after 24 hours. In this study, dorsal longitudinal incision of spinal cord on SCI rats was
performed at 72 hours after SCI to remove the liquefi ed necrotic gray matter. The results indicated
that after myelotomy, locomotor function of hindlimbs signifi cantly improved from 21st day after SCI.
There was also increased residual white matter area at the rostral and caudal segments to the injury
center when examined at day 42 after the injury. These results suggested that myelotomy at 72 hours
after injury has protective effect on the spinal cord.
- Full text:P020150710479966110332.pdf
