Congenital epulis: immunohistochemical findings of 12 cases
- Author:
Ajura Abdul Jalil
;
Lukman Md Auzair
;
Lau Shin Hin
- Publication Type:Journal Article
- Keywords:
alveolar ridge;
congenital epulis;
histogenesis;
immunohistochemistry;
newborn
- MeSH:
Gingival Neoplasms
- From:Archives of Orofacial Sciences
2015;10(1):34-40
- CountryMalaysia
- Language:English
-
Abstract:
Congenital epulis is a fairly rare soft tissue tumour occurring exclusively on the alveolar ridge of
newborns. The exact origin of congenital epulis is still debatable. The objective of the study is to determine the
clinicopathological features and immunohistochemical findings of congenital epulis. A retrospective study was
carried out to determine the clinicopathological features of congenital epulis, diagnosed histologically in the main
oral histopathology laboratory in Malaysia from 1967 to 2014. Immunostaining using vimentin, muscle specific
actin, smooth muscle antigen, desmin, S100, CD34, CD68 and CD1a was carried out. Twelve cases of
congenital epulis were reviewed. All of the patients were females and the presentation age ranged from 2 to 90
days. The patients comprised of 6 Malays, 3 Chinese, 2 Indians and 1 Orang Asli. Most of the cases (n=7)
involved the maxillary ridge and presented as pedunculated well-defined lumps (n=8). Excisional biopsy was
performed in all cases. Via immunohistochemistry, vimentin expression was observed in all cases; but negative
for CD34, muscle specific actin, smooth muscle antigen, and desmin. CD1a and S100 positivity was seen in five
cases. The interstitial cells were highlighted by CD68. Although congenital epulis has been first described 130
years ago, the exact nature of its histogenesis remains a mystery.
- Full text:P020150708482391577919.pdf
