MRI features and anti-AQP4 antibody status in Idiopathic infl ammatory demyelinating CNS disease (IIDCD) in Thai patients
- Author:
Naraporn Prayoonwiwat
;
Orasa Chawalparit
;
Waraporn Pienpuck
;
Chanon Ngamsombat
;
Jitsupa Wongsripuemtet
;
Sasitorn Siritho
- Publication Type:Journal Article
- From:Neurology Asia
2013;18(1):73-81
- CountryMalaysia
- Language:English
-
Abstract:
Objective: To evaluate the MRI fi ndings in different status of anti-aquaporin 4 (AQP4) antibody in Thai
patients with idiopathic infl ammatory demyelinating CNS diseases (IIDCDs). Methods: A retrospective
study of 135 IIDCDs patients was performed. The available brain and spinal MRI were reviewed.
All were tested for anti-AQP4 antibody. The MRI fi ndings were analyzed for any difference between
patients with seronegative and seropositive anti-AQP4 antibody. Results: Eighty cases included 47
seronegative and 33 seropositive anti-AQP4 antibody were reviewed. Forty seven brain and 20 spinal
MRIs from the seronegative group and 32 brain MRIs and 27 spinal MRIs (one with only spinal MRI)
from the seropositive group were analyzed. There was no signifi cant difference between the two groups
upon the number of patients who fulfi lled Barkhof’s MRI Criteria. When the patients were classifi ed
according to the location and pattern of abnormal MRI fi ndings, more cases in the seropositive group
had lesions at corticospinal tract or subependymal third/fourth ventricles (p<0.05). Long-extensive
spinal cord lesion and central gray matter location were found more in the seropositive group whereas
the short segment, peripheral location were found more in the seronegative group (p<0.05). Most of
the seropositive cases had lesions at the cervicothoracic level in contrast to the seronegative cases
which had more lesions at the thoracic cord level.
Conclusion: MRI features were different between IIDCDs patients with seronegative and seropositive
anti-AQP4 antibody. The characteristics and locations of the MRI lesions were mo
- Full text:P020150703597840325920.pdf
