Characteristics of epilepsy and immunological markers in epileptic patients after infl uenza associated encephalopathy
- Author:
Jun Mine
;
Yukitoshi Takahashi
;
Yuki Mogami
;
Hiroko Ikeda
;
Yuko Kubota
;
Katsumi Imai
- Publication Type:Journal Article
- From:Neurology Asia
2013;18(1):35-45
- CountryMalaysia
- Language:English
-
Abstract:
Objective: This study aimed to elucidate the electro-clinical characteristics of epilepsy and immunological
markers in patients with epilepsy after infl uenza-associated encephalopathy/encephalitis (IAE). Methods:
Eighteen patients with epilepsy after IAE (8 males, 10 females; mean age of onset 6.4±6.4 years)
were studied. Antibodies to glutamate receptor (GluR) ε2 (NR2B) were examined by immunoblot
and ELISA. Cytokines were measured by BioPlex. Results: Mean interval between IAE and epilepsy
onset was 63.2 ± 95.0 days (mean ± SD). In 16 of 18 patients, complex partial seizures were observed.
Most complex partial seizures were of short durations and showed few lateralizing signs. Interictal
discharges were seen in the frontal area in 7 of 14 patients. Ictal EEG showed rapid propagation to
bilateral hemispheres. Patients with higher cerebrospinal fl uid levels of anti-GluRε2 antibodies, higher
cerebrospinal fl uid levels of IL-1β, soluble tumor necrosis factor receptor 1 and IFN-γ during chronic
stage, had higher frequency of epileptic seizures.
Conclusion: This study indicates that the frontal lobes are susceptible to rapid epileptogenesis after
IAE, and that epileptic partial seizures after IAE had characteristics resembling generalized seizures.
Presence of anti-GluRε2 antibodies and elevated IL-1β, TNFα, and IFN-γ in cerebrospinal fl uid may
be associated with intractability of epileptic seizures.
- Full text:P020150703586466100298.pdf
