NT-proBNP levels and QT changes in acute ischemic stroke
- Author:
Ayca Acikalin
;
Salim Satar
;
Onur Akpinar
;
Caglar Emre Cagliyan
;
Mustafa Sahan
;
Ferhat Icme
;
Muge Gulen
;
Mehmet Yildiz
- Publication Type:Journal Article
- From:Neurology Asia
2013;18(1):1-8
- CountryMalaysia
- Language:English
-
Abstract:
Background: In literature, electrocardiographic (ECG) changes and the increase in the levels of the
natriuretic peptide are shown to occur in patients having acute ischemic stroke. We aimed to investigate
the association between ECG alterations and NT pro B-type natriuretic peptide (NT-proBNP) values
in patients having acute ischemic stroke with no known cardiac pathology. Methods: The patients who
admitted to the emergency service with acute ischemic stroke were enrolled in the study. Their ECGs
were recorded and serum samples were obtained as soon as they arrived into the emergency service.
The plasma NT-proBNP levels were measured by electrochemiluminescence method. Maximum QT
interval, QT dispersion (QTd), corrected QT and corrected QTd (cQT and cQTd) was calculated, for
each ECG. The patients were evaluated according to the Glasgow Coma Scale (GCS) and National
Institutes of Health Stroke Scale (NIHSS). Results: A total of 50 consecutive patients were evaluated.
QT intervals for 4 patients (8%) and cQT intervals for 29 patients (58%) were above 440 ms and 11
patients (22%) had QTd values above 50ms and 17 (34%) had cQTd values above 50 ms. The NTproBNP
levels had a negative correlation with the GCS (p=0.001, r= -0.461) and a positive correlation
with the NIHSS, cQT, QTd and cQTd (p=0.001, r=0.444, p=0.000, r=0.494, p=0.016, r=0.338 p=0.011,
r=0.355, respectively).
Conclusions: The NT-proBNP levels in the ischemic stroke patients with no known cardiac pathology
were markedly increased, and this increase was found to be associated with the GCS, NIHSS, cQT,
QTd and the cQTd interval.
- Full text:P020150703567041108346.pdf
