Associations of MRI-lesions and clinical features with disability in Chinese patients with multiple sclerosis

Author: Xiao-Juan Cheng ; Cheng ; Lin Miao ; Zheng-Liang Guo ; Yang-Tai Guan ; Zhen-Guo Liu ; Xin Wang ; Xiao-Jiang Sun ; Zhong-Xin Zhao ; Yong-Jian Song ; Xiao-Yi Ding ; Sheng-Di Chen ; Guo-Xin Jiang ; Fredrikson M
Publication Type:Journal Article
From:Neurology Asia 2013;18(4):391-399
CountryMalaysia
Language:English
Abstract: Objective: To analyze associations of MRI-lesions and clinical features with disability in patients with multiple sclerosis (MS) in Shanghai, China. Methods: We studied patients with MS, identified from a survey in Shanghai, whose sites of lesions in the CNS was based on the MRI examinations. Associations between MRI-lesions, various clinical variables and the severity of disability were analyzed with univariate and multivariate logistic regression analysis. Results: There were 210 patients in this study. The disability of the patients with lesions confined to the spinal cord was significantly more severe than those with lesions in the brain (p < 0.008). Current age (OR: 1.041, 95% CI: 1.007~1.077), MS duration (OR: 1.082, 95% CI: 1.011~1.159) and MRI-lesions in the spinal cord (OR: 2.441, 95% CI: 1.039~5.737) were significantly associated with severity of disability on multivariate logistic regression analysis. Conclusion: MRI-lesions in the spinal cord, older age, a longer MS duration were significantly associated with a more severe disability in this MS study in Shanghai China.
Full text:P020150702599267017428.pdf