Cold allodynia as the presenting symptom in a case of acquired neuromyotonia (Isaacs syndrome) with multiple autoantibodies
- Author:
Khean-Jin Goh
;
Suhailah Abdullah
;
Won Fen Wong
;
Swan-Sim Yeap
;
Nortina Shahrizaila
;
Chong-Tin Tan
- Publication Type:Journal Article
- From:Neurology Asia
2014;19(4):409-412
- CountryMalaysia
- Language:English
-
Abstract:
We report a patient who presented with severe cold-induced allodynia and hyperhidrosis, and found to
have acquired neuromyotonia (Isaacs syndrome) with high voltage-gated potassium channel (VGKC)
antibody titre,positive contactin-associated protein 2 (CASPR2) and leucine-rich glioma-inactivated
1 (LGI1) antibodies. The patient also had positive anti-dsDNA and acetylcholine receptor (AChR)
antibodies without clinical features of SLE or myasthenia gravis, suggesting a strong underlying
autoimmune tendency. CT thorax showed no thymoma. Her symptoms improved with intravenous
immunoglobulin infusion but recurred despite maintenance oral corticosteroids and carbamazepine.
She has since been on regular IVIG infusions. Cold allodynia is an unusual presentation in acquired
neuromyotonia.
- Full text:P020150701424351482874.pdf
