The neuroprotective effects of grape seed proanthocyanidin on rat brain injury caused by chronic intermittent hypoxia
- Author:
Ya-Ning Zhao
;
Xia Guo
;
Hong-Yang Wang
;
Lin Li
;
Pan-Pan Zhang
;
Xiao-Qing Han
;
Wen-Qian Liu
- Publication Type:Journal Article
- From:Neurology Asia
2014;19(4):399-403
- CountryMalaysia
- Language:English
-
Abstract:
Chronic intermitted hypoxia including sleep breathing disorder leads to brain injury. This study explores
the potential therapeutic effects of grape seed proanthocyanidin as a neuroprotective agent. A rat model
of chronic intermittent hypoxia was employed, and the animals were given low or high doses of grape
seed proanthocyanidin. The ultrastructure changes in the brain, the biochemical components, and the
animal behavior were examined. The results showed that with hypoxia exposure, neuronal mitochondria
exhibited injuries at ultrastructural level, with increased malondialdehyde (MDA) content and reduced
superoxide dismutase (SOD) activity. Terminal deoxynucleotidyl transferase dUTP nick end labeling
(TUNEL) staining revealed increased cell apoptosis in hippocampus. In Morris water maze the animals
showed decreased learning abilities, when compared to normal control. The administration of grape
seed proanthocyanidin treatment reversed all these observed changes, and improved the learning
behavior. We concluded that grape seed proanthocyanidin could alleviate the brain injury caused by
hypoxia from sleep breathing disorder.
- Full text:P020150701397256322908.pdf
