Volume estimation of the subcortical structures in Parkinson’s disease using magnetic resonance imaging: A methodological study
- Author:
Tolga Ertekin
;
Niyazi Acer
;
Semra çer
;
Ümit Erkan Vurdem
;
erife Çınar
;
Özlem Özçelik
- Publication Type:Journal Article
- MeSH:
Parkinson Disease
- From:Neurology Asia
2015;20(2):143-153
- CountryMalaysia
- Language:English
-
Abstract:
Background & Objectives: Parkinson’s disease (PD) is the most prevalent neurodegenerative disorder,
beginning in the in the substantia nigra and spreading to the subcortical structures to the limbic cortices,
and eventually to the neocortex and is characterized clinically by tremor at rest, bradykinesia, and
rigidity. Regional brain atrophy is found to be an important marker of PD’s pathology. The aim of the
current study was to compare the volumes of subcortical brain structures between healthy subjects
and patients with PD using stereological (point-counting) and semi-automated segmentation methods.
Methods: Twenty-four patients with PD and 23 age matched healthy subjects free of any psychiatric,
neurological or cognitive impairment were included in our study. Magnetic resonance images were
analyzed by using two methods. Results: Both methods showed a decrease in volume of caudate nucleus
and lentiform nucleus in PD group compared to the control group. (p˂0.05). However, no significant
differences was found between patient and control groups for the volume of thalamus (p>0.05). Also,
no significant difference was found between point-counting and semi-automated segmentation methods
for the volumes of subcortical structures in both two groups (p>0.05).
Conclusion: Magnatic resonance imaging is helpful to facilitate the diagnosis in vivo of patients with
PD, revealing atrophy of specific brain regions such as caudate nucleus and lentiform nucleus.
- Full text:P020150707339647675017.pdf
