Polymorphisms of nitric oxide synthase and GTP cyclohydrolase I genes in Japanese patients with medication overuse headaches
- Author:
Masakazu Ishii
;
Mirei Yahara
;
Hirotaka Katoh
;
Mitsuru Kawamura
;
Shunichi Shimizu
- Publication Type:Journal Article
- From:Neurology Asia
2014;19(3):277-281
- CountryMalaysia
- Language:English
-
Abstract:
We investigated whether polymorphisms of the endothelial nitric oxide synthase (eNOS), neuronal
NOS (nNOS), and GTP cyclohydrolase I (GTPCH) genes are involved in the aggravation of migraine
induced by overuse of medications. We studied 47 patients with migraine (six males and 41 females;
36.4 ± 10.3 years of age) and 22 patients with migraine exhibiting medication overuse headache (MOH,
one male and 21 females; 39.6 ± 9.9 years of age). The genotypes of polymorphisms of the eNOS
(rs1799983), nNOS (rs2682826), and GTPCH (rs841) genes were analyzed using the polymerase chain
reaction-restriction fragment length polymorphism (PCR-RFLP) method. The genotypic distributions of
rs2682826 (T/T plus T/C vs. C/C, P = 0.254), rs1799983 (G/G vs. G/T plus T/T, P = 1.000), and rs841
(T/T plus T/C vs. C/C, P = 0.149) were not significantly different between patients with migraine and
patients with MOH. The results of this study showed an absence of association between the polymorphisms
of eNOS, nNOS, and GTPCH genes and the complication of MOH in patients with migraine.
- Full text:P020150630474666954235.pdf
