Characteristics of familial multiple sclerosis in Isfahan, Iran: A cross-sectional study
- Author:
Nafiseh Toghianifar
;
Masoud Etemadifar
;
Ayda Sharifzadeh
;
Zahra Nasr
- Publication Type:Journal Article
- From:Neurology Asia
2014;19(1):59-62
- CountryMalaysia
- Language:English
-
Abstract:
Background & Objectives:Multiple sclerosis (MS) is one of the most common demyelinating diseases
of the central nervous system. The disease occurs with higher frequency among families. This study
aimed to investigate the frequency and type of familial MS among patients with definite MS registered
in the Isfahan Society for MS. Methods: A cross sectional study was performed on 3911 MS patients in
Isfahan. All patients had a diagnosis of definite MS. Demographic characteristics, medical history, signs
and symptoms at onset, course of disease, having a relative with MS, degree and type of relationship
were recorded. Results: Familial MS was found in 11% of patients, with 57. 7% having a first degree
relative with MS. Mean age of patients with familial MS was 36.9±10.4 years, with higher rates among
women (female to male ratio 2.6). Highest rate for familial MS was observed in sister-sister relations,
and brother-sister relation. Lowest rate was observed in father-son relation.
Conclusions: Familial MS is more common among sisters while father-son relationship has the lowest
association. Female to male ratio is 2.6 in familial MS which shows higher rates of males relative to
general population.
- Full text:P020150623567727582729.pdf
