Subclinical Hypothyroidism among Patients with Depressive Disorders
- Author:
Siti Yazmin Zahari Sham
;
Nor Aini Umar
;
Zarida Hambali
;
Rosdinom Razali
;
Mohd Rizal Abdul Manaf
- Publication Type:Journal Article
- Keywords:
Subclinical hypothyroid;
prevalence;
depressed patients, anti-thyroid peroxidase antibody
- MeSH:
Depression
- From:Malaysian Journal of Medicine and Health Sciences
2014;10(2):71-78
- CountryMalaysia
- Language:English
-
Abstract:
Subclinical hypothyroidism (SHT) is a biochemical diagnosis, defined as an elevated Thyroid Stimulating
Hormone (TSH) with normal free thyroxine (FT4). It affects 4-10% of the adult population and is
more prevalent in elderly women. Its commonest cause is autoimmune thyroiditis, detected by antithyroid
peroxidase antibody (TPO-Ab). About 2-5% of SHT patients progress to overt hypothyroidism
annually. The SHT prevalence among depressed patients ranges between 3% and 17%. This study aimed
to determine the prevalence of SHT and TPO-Ab positivity among patients diagnosed with depressive
disorders. It was a cross-sectional study carried out in the Universiti Kebangsaan Malaysia Medical
Centre over a 12 months period. Serum TSH, FT4 and TPO-Ab were measured. Results showed that
82% of depressed patients were euthyroid, 4% had SHT, 11% had subclinical hyperthyroidism and 2%
had discordant thyroid function. TPO-Ab positivity among the subjects was 7%, one of whom had SHT.
In conclusion, the prevalence of SHT and TPO-Ab positivity in the study population, at 4% and 7%,
respectively, were comparable to previous findings.
- Full text:P020150604541258888965.pdf
