Sensitivity and Specificity of Vestibular Evoked Myogenic Potential Elicited By Different Tone Bursts to Diagnose Peripheral Vestibular Disordered
- Author:
Zuraida Zainun
;
Mohd Normani Zakaria
;
Din Suhaimi Sidek
;
Zalina Ismail
- Publication Type:Journal Article
- Keywords:
Sensitivity;
specificity;
Vestibular evoked myogenic potentials;
Peripheral vestibular
- MeSH:
Vestibulocochlear Nerve Diseases
- From:Malaysian Journal of Medicine and Health Sciences
2014;10(2):9-17
- CountryMalaysia
- Language:English
-
Abstract:
Peripheral vestibular disorder (PVD) is serious and common. Clinically, giving an accurate diagnosis of
PVD can be challenging. Vestibular evoked myogenic potential (VEMP) is an objective test to evaluate
the integrity of vestibular organs, particularly saccule and/or inferior vestibular nerve. This study was
performed to determine the sensitivity and specificity of VEMP using different stimuli. Fourty normal
and 65 PVD subjects who fulfilled the inclusion criteria were recruited. While sitting comfortably,
VEMP waveforms were recorded with active electrode on sternocleidomastoid muscle and negative
electrode on upper forehead. Tone bursts (500, 750 and 1000 Hz) were delivered via headphones at 90
dBnHL and 5/s presentation rate. VEMP parameters for each stimulus (amplitude and latency of P1
and N1 peak) were analyzed accordingly. Receiver operating characteristic (ROC) was performed to
determine the sensitivity and specificity of VEMP at different test frequencies. N1 amplitude of 750 Hz
stimulus produced the most ideal sensitivity (65% on right and 63% on left) and specificity (83% on
right and 78% on left). The importance of using a few tone bursts in VEMP test in order to minimize the
false negative in cases might be encountered in clinics as the certain tone burst had inadequate sensitivity
in detecting PVD cases. The 750 Hz stimulus produced the most ideal VEMP with adequate values of
sensitivity and specificity, at least in this study.
- Full text:P020150604506771232139.pdf
