The relevance of micrornas in vascular aging
- Author:
Wong PF
;
Jong Hl
- Publication Type:Review
- Keywords:
Cellular senescene;
endothelial cells;
miR-299-3p
- MeSH:
MicroRNAs
- From:Journal of University of Malaya Medical Centre
2014;17(2):1-6
- CountryMalaysia
- Language:English
-
Abstract:
MicroRNAs (miRNAs) are short, single-stranded non-coding RNAs that control gene expression by annealing
to complementary sequences in mRNAs. They are estimated to regulate at least one third of human
transcripts and hence, manipulation of these miRNAs can profoundly affect the proteome and ultimately
cellular phenotypes. A substantial amount of work has shed light on the crucial roles of miRNAs in diseases.
miRNA expression profiles between normal and diseased tissues have identified miRNA signature patterns
that correlate to disease development and progression. This review discusses some of the important miRNAs
that are involved in endothelial cell senescence and dysfunction that contribute to the development and
progression of cardiovascular diseases.
- Full text:P020150603357994202129.pdf
