Cell-based therapy for the treatment of focal articular cartilage lesions: a review of six years of studies in a Malaysian University Medical Centre
- Author:
Samsudin EZ
;
Kamarul T
- Publication Type:Journal Article
- Keywords:
articular cartilage;
cell therapy;
autologous chondrocyte implantation;
animal studies;
review
- MeSH:
Cartilage, Articular
- From:Journal of University of Malaya Medical Centre
2014;17(2):1-11
- CountryMalaysia
- Language:English
-
Abstract:
Autologous chondrocyte implantation (ACI) is a significant technique that has gained widespread use for the
treatment of focal articular cartilage damage. Since its inception in 2004, the Tissue Engineering Group (TEG)
of the Faculty of Medicine, University Malaya has been dedicated to carrying out extensive research on this
cell-based therapy. The objective of this report, comprising one clinical case report, six animal studies and
one laboratory study, is to summarise and discuss TEG’s key findings. On the whole, we observed that the
ACI technique was effective in regenerating hyaline-like cartilage in treated defects. Autologous chondrocytes
and mesenchymal stem cells (MSC) were found to produce comparable tissue repair irrespective of the state
of MSC differentiation, and the use of alginate-based scaffolding and oral pharmacotherapy (Glucosamine
and Chondroitin Sulphate) was shown to enhance ACI-led tissue repair. ACI is suggested to be an efficient
therapeutic option for the treatment of articular cartilage defects of the knee.
- Full text:P020150603356166394762.pdf
