Phyllanthus sp a local plant with multiple medicinal properties
- Author:
Tang YQ
;
Lee SH
;
Sekaran SD
- Publication Type:Review
- Keywords:
anticancer;
antiviral;
broad spectrum antimicrobial;
dengue;
Phyllanthus
- MeSH:
Antineoplastic Agents;
Dengue
- From:Journal of University of Malaya Medical Centre
2014;17(2):1-8
- CountryMalaysia
- Language:English
-
Abstract:
The plants of the genus Phyllanthus (Euphorbiaceae) are distributed in most tropical and subtropical regions
of world. This plant has been long used as a traditional medicine to treat problems such as stomach, intestinal
infections, kidney and urinary bladder disturbances, diabetes, and hepatitis B. There has been considerable
interest in these plants in recent years. This review discusses the antiviral and anticancer aspects of Phyllanthus
species. Scientific studies have demonstrated that extracts and purified isolated compounds (flavonoids,
lignans, phenols, and terpenes) obtained from these plants possess antiviral effects against herpes simplex
(HSV) and dengue virus infections (DENV). These observations are associated with the disruption of essential
proteins needed during viral cycle, thus halting the viral replication. In addition, the Phyllanthus species have
also been shown to exert inhibitory effects against selected cancers types. In these studies anti-proliferative,
anti-metastatic, anti-angiogenic effects and induced apoptosis of human cancers cell lines were observed.
These may be explained by the disruption of multiple survival pathways and differential protein expression.
CONLCUSION:As a conclusion, tThe Phyllanthus plant possesses multiple medicinal properties, including
antiviral and anticancer activities which may potentially be used as a medicinal source for many disease locally.
- Full text:P020150603347404528227.pdf
