Flourescein Angiogram and Funduscopic Features of Radiation Induced Retinopathy: A Descriptive Value of Retinopathy Severity in Patients with Nasopharyngeal Carcinoma
- Author:
Norshamsiah MD
;
Wan Haslina Wah
;
Kok HS
;
Sharifa Ezat WP
;
Fuad I
- Publication Type:Journal Article
- Keywords:
nasopharyngeal carcinoma;
fluorescein fundus angiography;
retinopathy;
radiotherapy
- MeSH:
Nasopharyngeal carcinoma
- From:Medicine and Health
2015;10(1):23-31
- CountryMalaysia
- Language:English
-
Abstract:
Radiation retinopathy (RR) is a known complication after radiotherapy for
Nasopharyngeal Carcinoma (NPC). This study aims to relate the relationship of RR and radiation dose in patients with NPC through assessment with clinical
funduscopy and fundus fluorescein angiogram (FFA). A cross sectional study was
conducted on patients with NPC who had completed radiotherapy treatment in
the Oncology Clinic, Universiti Kebangsaan Malaysia Medical Centre (UKMMC).
Eighty two eyes of 42 patients were examined and the prevalence of RR was found
to be 35.4%. The severity of RR is strongly associated with the dose of radiation to
the retina (Spearman correlation value=0.48; p<0.001). The common features of
RR assessed by FFA were telangiectatic vessels (26.2%) and capillary non-perfusion
(14.3%). Retinal neovasularization occurred in 10.7% of eyes. The level of visual
deterioration correlated with the severity of RR with 26% of eyes experiencing a
visual acuity of 6/18 or worse. More than one third of patients developed RR, with
radiation maculopathy being the commonest cause for significant visual loss. FFA
is a useful tool in detecting early signs of radiation retinopathy and maculopathy.
Keywords:
